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KMID : 0624620230560090502
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BMB Reports
2023 Volume.56 No. 9 p.502 ~ p.507
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Photobiomodulation therapy activates YAP and triggers proliferation and dedifferentiation of Muller glia in mammalian retina
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Kim Seo-Yeon
Song Myung-Jun
Kim In-Beom
Park Tae-Kwan
Lyu Jung-Mook
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Abstract
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Photobiomodulation therapy has been proposed as a promising therapeutic approach for retinal degenerative diseases. However, its effect on the regenerative capacity in mammalian retina and its intracellular signalling mechanisms remain unknown. Here, we show that photobiomodulation with 670 nm light stimulates Muller glia cell cycle re-entry and dedifferentiation into a progenitor-like state in both the uninjured and injured retina. We also find that 670 nm light treatment inhibits the Hippo pathway, which is activated in Muller glia following NaIO3-induced retinal injury. YAP, a major downstream effector of the Hippo signalling pathway was translocated into the nucleus of Muller glia along with YAP dephosphorylation in retina treated with 670 nm light. Deficiency of YAP attenuated Muller glia cell cycle re-entry and dedifferentiation. Our data reveal that the Hippo-YAP signalling pathway is associated with the photostimulatory effect on regenerative response in mammalian retina, and suggest a potential therapeutic strategy for retinal degenerative diseases.
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KEYWORD
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Hippo pathway, Muller glia, Photobiomodulation, Regenerative potential, Retina
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